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Effect of Atherogenic Index of Plasma on Pre-Percutaneous Coronary Intervention Thrombolysis in Myocardial Infarction Flow in Patients With ST Elevation Myocardial Infarction.
- Source :
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Angiology [Angiology] 2024 Oct; Vol. 75 (9), pp. 841-848. Date of Electronic Publication: 2023 Jul 03. - Publication Year :
- 2024
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Abstract
- Dyslipidemia is an important risk factor for cardiovascular morbidity and mortality. Although low-density lipoprotein (LDL) is primarily responsible, the importance of triglyceride (TG) and high-density lipoprotein (HDL) has also been recognized. The present study investigated the effect of the atherogenic index of plasma (AIP), in which atherogenic and protective lipoproteins were evaluated together, on the initial flow in patients with ST elevation myocardial infarction. AIP was calculated as log(TG/HDL-cholesterol). Patients included in the study (n = 1535) were divided into Thrombolysis in Myocardial Infarction (TIMI) flow grade 0 and >0. AIP was found to be significantly different between 2 groups (.55 ± .23 vs .67 ± .21; P < .001). AIP was an independent predictor for pre-intervention TIMI flow (Odds Ratio: 2.778). A moderate correlation was found between TIMI frame count measurements, calculated in patients with TIMI 2-3, and AIP (Pearson correlation coefficient: .63, P < .001). In the receiver operating characteristic analysis, AIP showed the highest area under curve (AUC) compared with other lipid parameters for predicting vascular patency. The AUC of AIP was .634, the cut-off value was .59, and the sensitivity and specificity were 67.6% and 68.4%, respectively ( P < .001). In conclusion, AIP was found to be an important marker affecting pre-percutaneous coronary intervention TIMI flow.<br />Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Humans
Male
Female
Middle Aged
Aged
Thrombolytic Therapy methods
Cholesterol, HDL blood
Coronary Circulation physiology
ROC Curve
Atherosclerosis blood
Atherosclerosis physiopathology
Risk Factors
Predictive Value of Tests
Coronary Angiography
Dyslipidemias blood
Dyslipidemias complications
Dyslipidemias therapy
Dyslipidemias diagnosis
Vascular Patency
Treatment Outcome
ST Elevation Myocardial Infarction therapy
ST Elevation Myocardial Infarction blood
ST Elevation Myocardial Infarction physiopathology
Percutaneous Coronary Intervention
Triglycerides blood
Biomarkers blood
Subjects
Details
- Language :
- English
- ISSN :
- 1940-1574
- Volume :
- 75
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 37399526
- Full Text :
- https://doi.org/10.1177/00033197231185204