Start Over

HLA in isolated REM sleep behavior disorder and Lewy body dementia.

Authors :: Yu E
Krohn L
Ruskey JA
Asayesh F
Spiegelman D
Shah Z
Chia R
Arnulf I
Hu MTM
Montplaisir JY
Gagnon JF
Desautels A
Dauvilliers Y
Gigli GL
Valente M
Janes F
Bernardini A
Högl B
Stefani A
Ibrahim A
Heidbreder A
Sonka K
Dusek P
Kemlink D
Oertel W
Janzen A
Plazzi G
Antelmi E
Figorilli M
Puligheddu M
Mollenhauer B
Trenkwalder C
Sixel-Döring F
Cochen De Cock V
Ferini-Strambi L
Dijkstra F
Viaene M
Abril B
Boeve BF
Rouleau GA
Postuma RB
Scholz SW
Gan-Or Z
Source :: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2023 Sep; Vol. 10 (9), pp. 1682-1687. Date of Electronic Publication: 2023 Jul 04.
Publication Year :: 2023
Abstract: Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (p <subscript>omnibus</subscript> = 0.00102) and 70 (p <subscript>omnibus</subscript> = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.<br /> (© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)