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Synthesis and Characterization of a Luminescent Cyclic Poly(ethylene oxide)-Polypyridyl Ruthenium Complex.

Synthesis and Characterization of a Luminescent Cyclic Poly(ethylene oxide)-Polypyridyl Ruthenium Complex.

Authors :
Aboudzadeh MA
Rodríguez-Fanjul V
Terenzi A
Gónzalez de San Román E
Miranda JI
Pizarro AM
Salassa L
Barroso-Bujans F
Source :
ACS macro letters [ACS Macro Lett] 2023 Jul 18; Vol. 12 (7), pp. 999-1004. Date of Electronic Publication: 2023 Jul 05.
Publication Year :
2023

Abstract

We report the synthesis of a macrocyclic poly(ethylene oxide) (PEO) connected by one [Ru(bpy) <subscript>3</subscript> ] <superscript>2+</superscript> unit (where bpy = 2,2'-bipyridine), a photoactive metal complex that provides photosensitivity and potential biomedical applications to this polymer structure. The PEO chain provides biocompatibility, water solubility, and topological play. The macrocycles were successfully synthesized by copper-free click cycloaddition between a bifunctional dibenzocyclooctyne (DBCO)-PEO precursor and 4,4'-diazido-2,2'-bipyridine, followed by complexation with [Ru(bpy) <subscript>2</subscript> Cl <subscript>2</subscript> ]. The cyclic product accumulated efficiently in MCF7 cancer cells and exhibited a longer fluorescence lifetime than its linear analogue, likely due to differences in the accessibility of the ligand-centered/intraligand states of Ru polypyridyls in both topologies.

Details

Language :
English
ISSN :
2161-1653
Volume :
12
Issue :
7
Database :
MEDLINE
Journal :
ACS macro letters
Publication Type :
Academic Journal
Accession number :
37406348
Full Text :
https://doi.org/10.1021/acsmacrolett.3c00225