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Epitopes, paratopes, and other topes 30 years on: Understanding what we are talking about.
- Source :
-
Human immunology [Hum Immunol] 2023 Sep; Vol. 84 (9), pp. 429-438. Date of Electronic Publication: 2023 Jul 06. - Publication Year :
- 2023
-
Abstract
- The question of which protein antigens, such as HLA class I or class II molecules, will bind, and how well, to a given antibody is often assumed to depend exclusively on the details of protein surface structure. These structures are usually based on static models resulting from X-ray crystallography. While these notions are useful, the ultimate causal factors determining how well a given antigen binds a given antibody are based in thermodynamics and can include atomic mobility and the time-varying conformations of proteins. In this article, fundamental biophysical principles of antibody-antigen interaction are discussed, concepts critical for a deeper understanding of the pertinent molecular phenomena are highlighted, and common misunderstandings are identified and debunked.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Epitopes
Binding Sites, Antibody
Antigens
Antibodies
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1166
- Volume :
- 84
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Human immunology
- Publication Type :
- Academic Journal
- Accession number :
- 37407356
- Full Text :
- https://doi.org/10.1016/j.humimm.2023.06.006