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Advancements in understanding the role of microRnas in regulating macrophage polarization during acute lung injury.
- Source :
-
Cell cycle (Georgetown, Tex.) [Cell Cycle] 2023 Jul-Aug; Vol. 22 (14-16), pp. 1694-1712. Date of Electronic Publication: 2023 Jul 06. - Publication Year :
- 2023
-
Abstract
- Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical and life-threatening illness that causes severe dyspnea, and respiratory distress and is often caused by a variety of direct or indirect factors that damage the alveolar epithelium and capillary endothelial cells, leading to inflammation factors and macrophage infiltration. Macrophages play a crucial role in the progression of ALI/ARDS, exhibiting different polarized forms at different stages of the disease that control the disease outcome. MicroRNAs (miRNA) are conserved, endogenous, short non-coding RNAs composed of 18-25 nucleotides that serve as potential markers for many diseases and are involved in various biological processes, including cell proliferation, apoptosis, and differentiation. In this review, we provide a brief overview of miRNA expression in ALI/ARDS and summarize recent research on the mechanism and pathways by which miRNAs respond to macrophage polarization, inflammation, and apoptosis. The characteristics of each pathway are also summarized to provide a comprehensive understanding of the role of miRNAs in regulating macrophage polarization during ALI/ARDS.
Details
- Language :
- English
- ISSN :
- 1551-4005
- Volume :
- 22
- Issue :
- 14-16
- Database :
- MEDLINE
- Journal :
- Cell cycle (Georgetown, Tex.)
- Publication Type :
- Academic Journal
- Accession number :
- 37415386
- Full Text :
- https://doi.org/10.1080/15384101.2023.2230018