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AMBAR - Interactive Alteration annotations for molecular tumor boards.

Authors :: Fürstberger A
Ikonomi N
Kestler AMR
Marienfeld R
Schwab JD
Kuhn P
Seufferlein T
Kestler HA
Source :: Computer methods and programs in biomedicine [Comput Methods Programs Biomed] 2023 Oct; Vol. 240, pp. 107697. Date of Electronic Publication: 2023 Jul 06.
Publication Year :: 2023
Abstract: Motivation: Personalized decision-making for cancer therapy relies on molecular profiling from sequencing data in combination with database evidence and expert knowledge. Molecular tumor boards (MTBs) bring together clinicians and scientists with diverse expertise and are increasingly established in the clinical routine for therapeutic interventions. However, the analysis and documentation of patients data are still time-consuming and difficult to manage for MTBs, especially as few tools are available for the amount of information required.<br />Results: To overcome these limitations, we developed an interactive web application AMBAR (Alteration annotations for Molecular tumor BoARds), for therapeutic decision-making support in MTBs. AMBAR is an R shiny-based application that allows customization, interactive filtering, visualization, adding expert knowledge, and export to clinical systems of annotated mutations.<br />Availability: AMBAR is dockerized, open source and available at https://sysbio.uni-ulm.de/?Software:Ambar Contact:hans.kestler@uni-ulm.de.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)