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The implications of concomitant mucosal inflammation on clinical manifestations and outcomes of sinonasal inverted papilloma.
- Source :
-
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2023 Nov; Vol. 280 (11), pp. 4963-4968. Date of Electronic Publication: 2023 Jul 15. - Publication Year :
- 2023
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Abstract
- Purpose: This study examines the impact of concomitant mucosal inflammation on clinical manifestations and long-term outcomes of Inverted Papilloma (IP).<br />Methods: This retrospective cohort study was conducted in five tertiary medical centers. The included patients underwent an attachment-oriented surgical resection for IP with a minimum follow-up of 3 years.<br />Results: Of 185 patients with IP, 65 patients (35.1%) had synchronous mucosal inflammation with polypoid changes. The mean age was 56.7 years, and 69% were males. Most tumors originated from the maxillary sinus. Age, gender, Krouse stage, and tumor attachment site did not differ between the mucosal inflammation and IP-only groups. IP recurrence rate was twofold in the patients with mucosal inflammation (15.4% vs. 7.5%, p = 0.092). However, the difference was not significant, with a similar median time to recurrence between the two groups [15.5 (3-36) months vs. 16(6-96) months, p = 0.712]. In revision cases, IP recurred only in patients with mucosal inflammation (19% vs. 0%, p = 0.07). This group had a significantly worse 5-years recurrence-free survival than revision cases without mucosal inflammation (80.6% vs. 100%, p = 0.04).<br />Conclusions: IP in the setting of mucosal inflammation might be associated with a higher recurrence rate, predominantly after revision surgery. Otolaryngologists should consider this during these patients' diagnosis, surgical planning, and follow-up.<br /> (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Male
Humans
Middle Aged
Female
Retrospective Studies
Endoscopy
Neoplasm Recurrence, Local surgery
Inflammation
Paranasal Sinus Neoplasms complications
Paranasal Sinus Neoplasms surgery
Paranasal Sinus Neoplasms pathology
Papilloma, Inverted complications
Papilloma, Inverted surgery
Papilloma, Inverted pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1434-4726
- Volume :
- 280
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 37452833
- Full Text :
- https://doi.org/10.1007/s00405-023-08088-5