Back to Search
Start Over
Hericium erinaceus , in combination with natural flavonoid/alkaloid and B 3 /B 8 vitamins, can improve inflammatory burden in Inflammatory bowel diseases tissue: an ex vivo study.
- Source :
-
Frontiers in immunology [Front Immunol] 2023 Jul 03; Vol. 14, pp. 1215329. Date of Electronic Publication: 2023 Jul 03 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- Hericium erinaceus , berberine, and quercetin are effective in experimental colitis. It is unknown whether they can ameliorate inflammatory bowel diseases in humans. This ex vivo study aimed to evaluate the anti-inflammatory potential of a nutraceutical compound of HBQ-Complex <superscript>®</superscript> ( H. erinaceus , berberine, and quercetin), biotin, and niacin in inflammatory bowel disease patients. Tissue specimens were obtained either from Normal-Appearing Mucosa (NAM) or from Inflamed Mucosa (IM) in 20 patients with inflammatory bowel disease. mRNA and protein expression of COX-2, IL-10, and TNF-α were determined in NAM and IM biopsy samples (T0). IM samples were then incubated in HBQ-Complex <superscript>®</superscript> (with the addition of niacin and biotin), and COX-2, IL-10, and TNF-α tissue levels were evaluated at 120 minutes (T1) and 180 minutes (T2). Incubation with this compound resulted in a progressive decrease in gene and protein COX-2 and TNF-α expression at T1/T2 in the IM. IL-10 showed an opposite trend, with a progressive increase of mRNA and protein expression over the same time window. HBQ-Complex <superscript>®</superscript> (with the addition of niacin and biotin) decreased the expression of proinflammatory cytokines at the mRNA and protein levels in IBD tissue. On the contrary, mRNA and protein expression of the anti-inflammatory cytokine IL-10 showed a progressive increase.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Gravina, Pellegrino, Palladino, Coppola, Brandimarte, Tuccillo, Ciardiello, Romano and Federico.)
- Subjects :
- Humans
Interleukin-10 genetics
Interleukin-10 metabolism
Tumor Necrosis Factor-alpha metabolism
Vitamins metabolism
Flavonoids
Biotin metabolism
Quercetin metabolism
Cyclooxygenase 2 genetics
Cyclooxygenase 2 metabolism
Intestinal Mucosa metabolism
Cytokines metabolism
RNA, Messenger metabolism
Niacin metabolism
Berberine
Inflammatory Bowel Diseases metabolism
Antineoplastic Agents
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 37465689
- Full Text :
- https://doi.org/10.3389/fimmu.2023.1215329