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Association between High-Sensitivity C-Reactive Protein and Blood Pressure Variability in Subacute Stage of Ischemic Stroke.

Authors :
Xu C
Fu Z
Wu W
Zhang J
Liu M
Gao L
Source :
Brain sciences [Brain Sci] 2023 Jun 28; Vol. 13 (7). Date of Electronic Publication: 2023 Jun 28.
Publication Year :
2023

Abstract

The determinants of blood pressure variability (BPV) are complex. We aimed to evaluate whether circulating high-sensitivity C-reactive protein (hsCRP) is associated with short-term BPV during the subacute stage of ischemic stroke. In this observational study, a consecutive series of acute ischemic stroke patients who underwent 24 h ambulator blood pressure monitoring (ABPM) during day 4 to 10 after onset were enrolled. Multivariable linear regression models were constructed to assess relationships between hsCRP and BPV. Among a total of 325 patients analyzed, the mean age was 60 years old and 72% were male. The SD, CV, ARV of 24 h SBP and DBP were more likely to be higher in patients with hsCRP ≥ 2 mg/L, and these predispositions remained unchanged in linear regression analyses after adjusting for possible confounding factors, with a dose-response relationship when patients were additionally categorized into quartiles according to hsCRP levels using the lowest quartile as a reference category. In contrast, similar results were observed for the mean of SBP but not the mean of DBP. These results indicate that hsCRP is dose-dependently associated with short-term BPV during the subacute stage of ischemic stroke. These findings suggested that patients with a higher level of hsCRP tended to have larger blood pressure fluctuations.

Details

Language :
English
ISSN :
2076-3425
Volume :
13
Issue :
7
Database :
MEDLINE
Journal :
Brain sciences
Publication Type :
Academic Journal
Accession number :
37508930
Full Text :
https://doi.org/10.3390/brainsci13070998