δ-Opioid Receptor as a Molecular Target for Increasing Cardiac Resistance to Reperfusion in Drug Development.

Authors :: Naryzhnaya NV
Mukhomedzyanov AV
Sirotina M
Maslov LN
Kurbatov BK
Gorbunov AS
Kilin M
Kan A
Krylatov AV
Podoksenov YK
Logvinov SV
Source :: Biomedicines [Biomedicines] 2023 Jul 03; Vol. 11 (7). Date of Electronic Publication: 2023 Jul 03.
Publication Year :: 2023
Abstract: An analysis of published data and the results of our own studies reveal that the activation of a peripheral δ <subscript>2</subscript> -opioid receptor (δ <subscript>2</subscript> -OR) increases the cardiac tolerance to reperfusion. It has been found that this δ <subscript>2</subscript> -OR is localized in cardiomyocytes. Endogenous opioids are not involved in the regulation of cardiac resistance to reperfusion. The infarct-limiting effect of the δ <subscript>2</subscript> -OR agonist deltorphin II depends on the activation of several protein kinases, including PKCδ, ERK1/2, PI3K, and PKG. Hypothetical end-effectors of the cardioprotective effect of deltorphin II are the sarcolemmal K <subscript>ATP</subscript> channels and the MPT pore.

Full Text Access

Tools