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Heterogeneity of Glycolytic Phenotype Determined by 18 F-FDG PET/CT Using Coefficient of Variation in Patients with Advanced Non-Small Cell Lung Cancer.
- Source :
-
Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2023 Jul 22; Vol. 13 (14). Date of Electronic Publication: 2023 Jul 22. - Publication Year :
- 2023
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Abstract
- We investigated the role of Coefficient of Variation (CoV), a first-order texture parameter derived from <superscript>18</superscript> F-FDG PET/CT, in the prognosis of Non-Small Cell Lung Cancer (NSCLC) patients. Eighty-four patients with advanced NSCLC who underwent <superscript>18</superscript> F-FDG PET/CT before therapy were retrospectively studied. SUVmax, SUVmean, CoV, total Metabolic Tumor Volume (MTV <subscript>TOT</subscript> ) and whole-body Total Lesion Glycolysis (TLG <subscript>WB</subscript> ) were determined by an automated contouring program (SUV threshold at 2.5). We analyzed 194 lesions: primary tumors ( n = 84), regional ( n = 48) and non-regional ( n = 17) lymph nodes and metastases in liver ( n = 9), bone ( n = 23) and other sites ( n = 13); average CoVs were 0.36 ± 0.13, 0.36 ± 0.14, 0.42 ± 0.18, 0.30 ± 0.14, 0.37 ± 0.17, 0.34 ± 0.13, respectively. No significant differences were found between the CoV values among the different lesion categories. Survival analysis included age, gender, histology, stage, MTV <subscript>TOT</subscript> , TLG <subscript>WB</subscript> and imaging parameters derived from primary tumors. At univariate analysis, CoV ( p = 0.0184), MTV <subscript>TOT</subscript> ( p = 0.0050), TLG <subscript>WB</subscript> ( p = 0.0108) and stage ( p = 0.0041) predicted Overall Survival (OS). At multivariate analysis, age, CoV, MTV <subscript>TOT</subscript> and stage were retained in the model ( p = 0.0001). Patients with CoV > 0.38 had significantly better OS than those with CoV ≤ 0.38 ( p = 0.0143). Patients with MTV <subscript>TOT</subscript> ≤ 89.5 mL had higher OS than those with MTV <subscript>TOT</subscript> > 89.5 mL ( p = 0.0063). Combining CoV and MTV <subscript>TOT</subscript> , patients with CoV ≤ 0.38 and MTV <subscript>TOT</subscript> > 89.5 mL had the worst prognosis. CoV, by reflecting the heterogeneity of glycolytic phenotype, can predict clinical outcomes in NSCLC patients.
Details
- Language :
- English
- ISSN :
- 2075-4418
- Volume :
- 13
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Diagnostics (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 37510192
- Full Text :
- https://doi.org/10.3390/diagnostics13142448