Decoding the role of miRNAs in multiple myeloma pathogenesis: A focus on signaling pathways.

Authors :: Yehia AM
Elsakka EGE
Abulsoud AI
Abdelmaksoud NM
Elshafei A
Elkhawaga SY
Ismail A
Mokhtar MM
El-Mahdy HA
Hegazy M
Elballal MS
Mohammed OA
El-Husseiny HM
Midan HM
El-Dakroury WA
Zewail MB
Abdel Mageed SS
Moustafa YM
Mostafa RM
Elkady MA
Doghish AS
Source :: Pathology, research and practice [Pathol Res Pract] 2023 Aug; Vol. 248, pp. 154715. Date of Electronic Publication: 2023 Jul 26.
Publication Year :: 2023
Abstract: Multiple myeloma (MM) is a cancer of plasma cells that has been extensively studied in recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in regulating gene expression in MM. Several non-coding RNAs have been demonstrated to regulate MM pathogenesis signaling pathways. These pathways might regulate MM development, apoptosis, progression, and therapeutic outcomes. They are Wnt/β-catenin, PI3K/Akt/mTOR, P53 and KRAS. This review highlights the impending role of miRNAs in MM signaling and their relationship with MM therapeutic interventions.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier GmbH. All rights reserved.)

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