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Plasma Neurofilament Light Chain Is Elevated after Transcatheter Aortic Valve Implantation.
- Source :
-
Cardiology [Cardiology] 2023; Vol. 148 (5), pp. 478-484. Date of Electronic Publication: 2023 Jul 28. - Publication Year :
- 2023
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Abstract
- Introduction: Transcatheter aortic valve implantation (TAVI) is associated with a high incidence of new silent brain infarcts (SBIs) on postprocedural neuroimaging. A venous blood sample reflecting neuronal damage following TAVI could help identify patients with potential SBIs. We aimed to investigate if a biochemical marker of neuronal injury, neurofilament light chain (NFL), is elevated after TAVI.<br />Methods: In this observational study, NFL was measured in plasma from 31 patients before and after TAVI. Multivariable regression analysis was performed to investigate any effect of clinical- and procedure-related factors on differences in NFL levels before and after TAVI.<br />Results: Samples were collected 41 (14-81) days before and 44 (35-59) days after TAVI, median (interquartile range). Median age was 81 (77-84) years, and 35% were female. No patient had any overt procedure-related neurological complications. The geometric mean (95% confidence interval) of the NFL concentration was 30 (25-36) pg/mL before TAVI and 48 (39-61) pg/mL, after TAVI, p &lt;0.001. None of the included variables in the multiple linear regression model were statistically significantly associated with the difference in levels before and after TAVI.<br />Conclusions: NFL levels in plasma were higher after TAVI as compared with levels before, with a mean increase of 60% (18 pg/mL). Further studies including neuroimaging and cognitive outcomes are needed to understand the potential value of measuring NFL in relation to TAVI.<br /> (© 2023 The Author(s). Published by S. Karger AG, Basel.)
Details
- Language :
- English
- ISSN :
- 1421-9751
- Volume :
- 148
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 37517390
- Full Text :
- https://doi.org/10.1159/000532041