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Herpes Zoster Reactivation After mRNA and Adenovirus-Vectored Coronavirus Disease 2019 Vaccination: Analysis of National Health Insurance Database.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2023 Nov 11; Vol. 228 (10), pp. 1326-1335. - Publication Year :
- 2023
-
Abstract
- Background: Our study aimed to determine the risk of herpes zoster reactivation and coronavirus disease 2019 (COVID-19) vaccination (mRNA vaccine [BNT162b2] and adenovirus-vectored vaccine [ChAdOx1 nCoV-19]).<br />Methods: This retrospective study analyzed herpes zoster cases diagnosed between 26 February 2021 and 30 June 2021 and registered in the National Health Insurance Service database. A matched case-control study with a 1:3 matching ratio and a propensity score matching (PSM) study with a 1:1 ratio of vaccinated and unvaccinated individuals were performed.<br />Results: In the matched case control analysis, BNT162b2 was associated with an increased risk of herpes zoster reactivation (first dose adjusted odds ratio [aOR], 1.11; 95% confidence interval [CI], 1.06-1.15; second dose aOR, 1.17; 95% CI, 1.12-1.23). PSM analysis revealed a statistically significant increase in risk within 18 days following any vaccination (adjusted hazard ratio [aHR], 1.09; 95% CI, 1.02-1.16). BNT162b2 was associated with an increased risk at 18 days postvaccination (aHR, 1.65; 95% CI, 1.35-2.02) and second dose (aHR, 1.10; 95% CI, 1.02-1.19). However, the risk did not increase in both analyses of ChAdOx1 vaccination.<br />Conclusions: mRNA COVID-19 vaccination possibly increases the risk of herpes zoster reactivation, and thus close follow-up for herpes zoster reactivation is required.<br />Competing Interests: Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.<br /> (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
- Subjects :
- Humans
Adenoviridae genetics
BNT162 Vaccine
Case-Control Studies
ChAdOx1 nCoV-19
Herpesvirus 3, Human genetics
Retrospective Studies
Vaccination adverse effects
Vaccines, Attenuated adverse effects
Adenoviridae Infections
COVID-19 epidemiology
COVID-19 prevention & control
COVID-19 Vaccines adverse effects
Herpes Zoster epidemiology
Herpes Zoster prevention & control
Herpes Zoster Vaccine adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 228
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 37549237
- Full Text :
- https://doi.org/10.1093/infdis/jiad297