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Age- and dose-dependent effect of statin use on the risk of osteoporotic fracture in older adults.
- Source :
-
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2023 Nov; Vol. 34 (11), pp. 1927-1936. Date of Electronic Publication: 2023 Aug 08. - Publication Year :
- 2023
-
Abstract
- Previous studies have revealed the protective effects of statins on bone but the association of statins use with osteoporosis-related measurement has shown controversial results. In this study, we found an age, dose andduration-dependent osteoprotective effect of statins in general older population.<br />Purpose: Previous studies have revealed the protective effects of statins on bone but the association of statins use with osteoporotic fractures has shown controversial results.<br />Methods: In this study with Korean National Health Insurance Service-Senior cohort database, a total of 365,656 elderly without previous history of osteoporosis and who were started on statin since January 1 2004 were included and observed until December 31 2012. Hazard rations (HR) for major osteoporotic fractures were calculated using the weighted Cox proportional hazards model with inverse-probability of treatment weighting method.<br />Results: During 6.27 years of follow-up period, 54,959 osteoporotic fractures occurred and the majority of fractures (69.5%) were vertebral fractures. Compared with non-users, statin use was associated with a decreased risk of all outcomes with adjusted HR (95% CI) of 0.77 (0.72-0.83; P < 0.001) for major osteoporotic fractures, 0.49 (0.38-0.62; P < 0.001) for hip fractures, and 0.70 (0.64-0.77; P < 0.001) for vertebral fractures. When outcomes were examined separately by sex, the results were broadly comparable in terms of patterns of risk reduction by statin use. The patients with statin initiated at age ≥ 80 years had the highest risk reduction for most outcomes relative to non-users. Higher cumulative dose of statin was negatively associated with the osteoporotic fracture risk; 0.97 (0.91-1.02) for 30-364 cumulative daily defined dose (cDDD), 0.45 (0.40-0.51) for 365-1,094 cDDD, and 0.22 (0.15-0.33) for ≥ 1,095 cDDD.<br />Conclusions: Our results showed that statin use was associated with significant reduction in the risk of osteoporotic fractures in general older population.<br /> (© 2023. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.)
- Subjects :
- Humans
Female
Male
Aged
Aged, 80 and over
Republic of Korea epidemiology
Hip Fractures prevention & control
Hip Fractures epidemiology
Hip Fractures etiology
Risk Assessment methods
Age Factors
Spinal Fractures prevention & control
Spinal Fractures epidemiology
Spinal Fractures etiology
Databases, Factual
Follow-Up Studies
Osteoporotic Fractures prevention & control
Osteoporotic Fractures epidemiology
Osteoporotic Fractures etiology
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage
Dose-Response Relationship, Drug
Subjects
Details
- Language :
- English
- ISSN :
- 1433-2965
- Volume :
- 34
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- Publication Type :
- Academic Journal
- Accession number :
- 37552294
- Full Text :
- https://doi.org/10.1007/s00198-023-06879-4