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Synthesis of 4-Alkylated 1,4-Dihydropyridines: Fe(II)-Mediated Oxidative Cascade Cyclization Reaction of Cyclic Ethers with Enaminones.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2023 Aug 18; Vol. 88 (16), pp. 11627-11636. Date of Electronic Publication: 2023 Aug 09. - Publication Year :
- 2023
-
Abstract
- Syntheses of highly functionalized 4-alkylated 1,4-dihydropyridines (1,4-DHPs) from cyclic ethers and enaminones via iron(II)-mediated oxidative free radical cascade C(sp <superscript>3</superscript> )-H bond functionalization/C(sp <superscript>3</superscript> )-O bond cleavage/cyclization reaction have been first developed. This novel synthetic strategy offers an alternative method for the construction of 1,4-DHPs by using esters as the C4 sources, as well as expands the application of ethers in heterocycle synthesis.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 88
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 37556793
- Full Text :
- https://doi.org/10.1021/acs.joc.3c00925