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A useful high-dose intermittent schedule of adriamycin and DTIC in the treatment of advanced sarcomas.

Authors :
Saiki JH
Baker LH
Rivkin SE
Shahbender S
Fletcher WS
Athens JW
Balcerzak SP
Bonnet JD
Source :
Cancer [Cancer] 1986 Nov 15; Vol. 58 (10), pp. 2196-7.
Publication Year :
1986

Abstract

One-hundred-fourteen evaluable patients with metastatic soft tissue or bony sarcoma with measurable disease were treated with Adriamycin (doxorubicin) administered intravenously at a dose of 60 mg/M2 on day 1, followed by DTIC (dacarbazine) at a dose of 750 mg/M2; courses were administered at 3-week intervals. Ten complete remissions and 17 partial remissions were observed. The most responsive cell type was malignant fibrous histiocytoma with a response rate of 54%. This treatment schedule was very well tolerated, with only moderate myelosuppression and moderate nausea and vomiting. Cardiac toxicity was identified in three patients, with two patients demonstrating electrocardiogram (EKG) changes and arrhythmias and only one patient developing heart failure. The 24% overall response rate suggests no compromise in activity on this schedule, with a significant reduction in toxicity.

Details

Language :
English
ISSN :
0008-543X
Volume :
58
Issue :
10
Database :
MEDLINE
Journal :
Cancer
Publication Type :
Academic Journal
Accession number :
3756766
Full Text :
https://doi.org/10.1002/1097-0142(19861115)58:10<2196::aid-cncr2820581005>3.0.co;2-j