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Evaluation of α-Glucosidase Inhibition and Antihyperglycemic Activity of Extracts Obtained from Leaves and Flowers of Rumex crispus L.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2023 Jul 30; Vol. 28 (15). Date of Electronic Publication: 2023 Jul 30. - Publication Year :
- 2023
-
Abstract
- Among antihyperglycemic drugs used for treating diabetes, α-glucosidase inhibitors generate the least adverse effects. This contribution aimed to evaluate the potential antidiabetic activity of Rumex crispus L. by testing its in vitro α-glucosidase inhibition and in vivo antihyperglycemic effects on rats with streptozotocin (STZ)-induced diabetes. Better inhibition of α-glucosidase was found with the methanol extract versus the n-hexane and dichloromethane extracts. The methanol extract of the flowers (RCFM) was more effective than that of the leaves (RCHM), with an IC <subscript>50</subscript> of 7.3 ± 0.17 μg/mL for RCFM and 112.0 ± 1.23 μg/mL for RCHM. A bioactive fraction (F89s) also showed good α-glucosidase inhibition (IC <subscript>50</subscript> = 3.8 ± 0.11 μg/mL). In a preliminary study, RCHM and RCFM at 150 mg/kg and F89s at 75 mg/kg after 30 days showed a significant effect on hyperglycemia, reducing glucose levels (82.2, 80.1, and 84.1%, respectively), and improved the lipid, renal, and hepatic profiles of the rats, comparable with the effects of metformin and acarbose. According to the results, the activity of R. crispus L. may be mediated by a diminished rate of disaccharide hydrolysis, associated with the inhibition of α-glucosidase. Thus, R. crispus L. holds promise for the development of auxiliary drugs to treat diabetes mellitus.
- Subjects :
- Rats
Animals
Hypoglycemic Agents pharmacology
Hypoglycemic Agents therapeutic use
alpha-Glucosidases
Methanol
Plant Extracts pharmacology
Plant Extracts therapeutic use
Glycoside Hydrolase Inhibitors pharmacology
Glycoside Hydrolase Inhibitors therapeutic use
Plant Leaves
Flowers
Rumex
Diabetes Mellitus, Experimental drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 28
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 37570730
- Full Text :
- https://doi.org/10.3390/molecules28155760