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Bismuth Oxide Composite-Based Agricultural Waste for Wound Dressing Applications.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2023 Aug 05; Vol. 28 (15). Date of Electronic Publication: 2023 Aug 05. - Publication Year :
- 2023
-
Abstract
- The purpose of this study was to enhance the antimicrobial activity of bagasse paper by coating the paper with bismuth oxide (Bi <subscript>2</subscript> O <subscript>3</subscript> ) and using it to accelerate the process of wound healing. Paper sheets were prepared from sugarcane waste (bagasse). First, the paper sheets were coated with different Bi <subscript>2</subscript> O <subscript>3</subscript> concentrations to improve the antimicrobial activity of the paper. After that, the paper sheets were allowed to dry in an oven at 50 °C for 3 h. Then, in vitro antimicrobial activity was evaluated against different microbial species, including Gram-negative bacteria (i.e., Klebsiella pneumonia, Escherichia coli) and Gram-positive bacteria (i.e., Staphylococcus aureus, Streptococcus pyogenes). The obtained results showed that the paper coated with 25% and 100% Bi <subscript>2</subscript> O <subscript>3</subscript> had activity against all models of bacteria; however, the paper coated with 100% Bi <subscript>2</subscript> O <subscript>3</subscript> composite had the strongest inhibitory effect. Then, bagasse paper was coated with 100% Bi <subscript>2</subscript> O <subscript>3</subscript> and different antibiotics, to investigate their wound-healing potency in a wounded rat model for 14 days. Moreover, the paper coated with 100% Bi <subscript>2</subscript> O <subscript>3</subscript> inhibited the cellular migration in vitro. Conclusively, coating paper with Bi <subscript>2</subscript> O <subscript>3</subscript> enhances the wound-healing potential when applied to wounds. This impact could be ascribed to Bi <subscript>2</subscript> O <subscript>3</subscript> 's broad antibacterial activity, which reduced infection and accelerated the healing process.
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 28
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 37570869
- Full Text :
- https://doi.org/10.3390/molecules28155900