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[Short-term outcome of patients after transcatheter aortic valve replacement receiving different anticoagulants].

Authors :
Sun YH
Li J
Luo SY
Zheng SN
Chen JH
Fu M
Li G
Fan RX
Luo JF
Source :
Zhonghua xin xue guan bing za zhi [Zhonghua Xin Xue Guan Bing Za Zhi] 2023 Aug 24; Vol. 51 (8), pp. 838-843.
Publication Year :
2023

Abstract

Objective: To compare the safety and efficacy of different anticoagulants in patients with indications for anticoagulation after transcatheter aortic valve replacement (TAVR). Methods: This is a retrospective study. Patients who underwent TAVR from April 2016 to February 2022 in Guangdong Provincial People's Hospital and had indications for anticoagulation were included and divided into two groups according to the type of anticoagulants, i.e. non-vitamin K antagonist oral anticoagulant (NOAC) and warfarin, and patients were followed up for 30 days. The primary endpoint was the combination of death, stroke, myocardial infarction, valve thrombosis, intracardiac thrombosis and major bleeding. The incidence of endpoints was compared between two groups, and multivariate logistic regression analysis was applied to adjust the bias of potential confounders. Results: A total of 80 patients were included. Mean age was (74.4±7.1) years, 43 (53.8%) were male. Forty-nine (61.3%) patients used NOAC, 31 used warfarin, and major indication for anticoagulants was atrial fibrillation (76/80, 95.0%). The adjusted risks of the primary endpoint ( OR =0.23, 95% CI 0.06-0.94, P =0.040) of NOAC were lower than that of warfarin, mainly driven by a lower risk of major bleeding ( OR =0.19, 95% CI 0.04-0.92, P =0.039). Conclusions: The short-term outcome of NOAC is better than that of warfarin in patients with indications for anticoagulation after TAVR. Randomized controlled trials of large sample size with long-term follow-up are needed to further testify this finding.

Details

Language :
Chinese
ISSN :
0253-3758
Volume :
51
Issue :
8
Database :
MEDLINE
Journal :
Zhonghua xin xue guan bing za zhi
Publication Type :
Academic Journal
Accession number :
37583332
Full Text :
https://doi.org/10.3760/cma.j.cn112148-20230629-00382