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Clinical and economic implications of epilepsy management across treatment lines in Spain: a real-life database analysis.
- Source :
-
Journal of neurology [J Neurol] 2023 Dec; Vol. 270 (12), pp. 5945-5957. Date of Electronic Publication: 2023 Aug 25. - Publication Year :
- 2023
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Abstract
- Background: Epilepsy is a chronic brain disease characterized by recurrent seizures. We investigated real-world management of epilepsy across treatment lines in Spain, including healthcare resource use (HRU) and associated costs.<br />Methods: This was a retrospective study of real-life data from epilepsy patients prescribed antiseizure medication (ASM) between January 2016 and December 2021. Patients were grouped according to their line of treatment (1st, 2nd, 3rd and 4th +) during the recruitment period. Demographic and clinical characteristics, comorbidities and concomitant medications were analyzed during the baseline period (6 months before starting treatment line); antiepileptic treatments, concomitant medications, HRU and associated costs were analyzed during follow-up.<br />Results: The study included 5006 patients. Treatment duration decreased as treatment lines progressed (mean ± SD progression time: 523.2 ± 279.1 days from 1st to 2nd line, 351.6 ± 194.4 days from 2nd to 3rd line; 272.7 ± 139.3 days from 3rd to 4th + line). Significant HRU differences were found with subsequent treatment lines, including an increase in hospital admissions and patients on sick leave. Mean (95% CI) adjusted total costs per patient were €2974/year (2773-3175) in the 1st line and €5735/year (5043-6428) in the 4th + line. There was an increase in adjusted direct and total costs with subsequent treatment lines; the mean difference in total costs between cohorts was €2761 (p < 0.001). The highest direct costs were associated with epilepsy medication, days at the hospital and specialist visits.<br />Conclusion: Our data revealed a progressive increase in the use of resources and associated costs across subsequent epilepsy treatment lines.<br /> (© 2023. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1432-1459
- Volume :
- 270
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 37626245
- Full Text :
- https://doi.org/10.1007/s00415-023-11958-x