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Pimaric acid reduces vasoconstriction via BK Ca channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles.
- Source :
-
Journal of pharmacological sciences [J Pharmacol Sci] 2023 Oct; Vol. 153 (2), pp. 84-88. Date of Electronic Publication: 2023 Aug 10. - Publication Year :
- 2023
-
Abstract
- Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance Ca <superscript>2+</superscript> -activated K <superscript>+</superscript> (BK <subscript>Ca</subscript> ) channels and inhibited voltage-dependent Ca <superscript>2+</superscript> channels (VDCCs). In the present study, PiMA attenuated vasoconstriction induced by high K <superscript>+</superscript> or endothelin-1 in rat pulmonary arterial smooth muscles (PASMs). PiMA also reduced high K <superscript>+</superscript> -induced cytosolic [Ca <superscript>2+</superscript> ] increase in PASM cells. PiMA increased BK <subscript>Ca</subscript> currents and decreased VDCC currents. BK <subscript>Ca</subscript> channels and VDCCs were formed by the α/β <subscript>1</subscript> and α <subscript>1C</subscript> /α <subscript>1D</subscript> /β <subscript>2</subscript> /β <subscript>3</subscript> subunits, respectively. These results indicate that PiMA induces vasorelaxation through the dual effects of BK <subscript>Ca</subscript> channel activation and VDCC inhibition in PASMs.<br />Competing Interests: Declaration of competing interest The authors indicated no potential conflicts of interest.<br /> (Copyright © 2023 The Authors. Production and hosting by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1347-8648
- Volume :
- 153
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 37640473
- Full Text :
- https://doi.org/10.1016/j.jphs.2023.08.001