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Mechanisms Involved in the Therapeutic Effect of Cannabinoid Compounds on Gliomas: A Review with Experimental Approach.

Authors :
Pires HFO
da Silva PR
Dias AL
de Sousa Gomes C
de Sousa NF
Dos Santos AMF
Souza LRP
de Figueiredo Lima JL
Oliveira MCN
Felipe CFB
de Almeida RN
de Castro RD
da Silva Stiebbe Salvadori MG
Scotti MT
Scotti L
Source :
Current protein & peptide science [Curr Protein Pept Sci] 2024; Vol. 25 (1), pp. 27-43.
Publication Year :
2024

Abstract

Introduction: Brain tumors have high morbidity and mortality rates, accounting for 1.4% of all cancers. Gliomas are the most common primary brain tumors in adults. Currently, several therapeutic approaches are used; however, they are associated with side effects that affect patients'quality of life. Therefore, further studies are needed to develop novel therapeutic protocols with a more favorable side effect profile. In this context, cannabinoid compounds may serve as potential alternatives.<br />Objective: This study aimed to review the key enzymatic targets involved in glioma pathophysiology and evaluate the potential interaction of these targets with four cannabinoid derivatives through molecular docking simulations.<br />Methods: Molecular docking simulations were performed using four cannabinoid compounds and six molecular targets associated with glioma pathophysiology.<br />Results: Encouraging interactions between the selected enzymes and glioma-related targets were observed, suggesting their potential activity through these pathways. In particular, cannabigerol showed promising interactions with epidermal growth factor receptors and phosphatidylinositol 3- kinase, while Δ-9-tetrahydrocannabinol showed remarkable interactions with telomerase reverse transcriptase.<br />Conclusion: The evaluated compounds exhibited favorable interactions with the analyzed enzymatic targets, thus representing potential candidates for further in vitro and in vivo studies.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Details

Language :
English
ISSN :
1875-5550
Volume :
25
Issue :
1
Database :
MEDLINE
Journal :
Current protein & peptide science
Publication Type :
Academic Journal
Accession number :
37649287
Full Text :
https://doi.org/10.2174/1389203724666230830125423