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The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance.
- Source :
-
Nature aging [Nat Aging] 2023 Sep; Vol. 3 (9), pp. 1128-1143. Date of Electronic Publication: 2023 Aug 31. - Publication Year :
- 2023
-
Abstract
- Changes in dopaminergic neuromodulation play a key role in adult memory decline. Recent research has also implicated noradrenaline in shaping late-life memory. However, it is unclear whether these two neuromodulators have distinct roles in age-related cognitive changes. Here, combining longitudinal MRI of the dopaminergic substantia nigra-ventral tegmental area (SN-VTA) and noradrenergic locus coeruleus (LC) in younger (n = 69) and older (n = 251) adults, we found that dopaminergic and noradrenergic integrity are differentially associated with memory performance. While LC integrity was related to better episodic memory across several tasks, SN-VTA integrity was linked to working memory. Longitudinally, we found that older age was associated with more negative change in SN-VTA and LC integrity. Notably, changes in LC integrity reliably predicted future episodic memory. These differential associations of dopaminergic and noradrenergic nuclei with late-life cognitive decline have potential clinical utility, given their degeneration in several age-associated diseases.<br /> (© 2023. The Author(s).)
Details
- Language :
- English
- ISSN :
- 2662-8465
- Volume :
- 3
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nature aging
- Publication Type :
- Academic Journal
- Accession number :
- 37653256
- Full Text :
- https://doi.org/10.1038/s43587-023-00469-z