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Nickel Catalyzed Carbonylation/Carboxylation Sequence via Double CO 2 Incorporation.
- Source :
-
Organic letters [Org Lett] 2023 Sep 29; Vol. 25 (38), pp. 6969-6974. Date of Electronic Publication: 2023 Sep 05. - Publication Year :
- 2023
-
Abstract
- A carbonylation-carboxylation synthetic sequence, via double CO <subscript>2</subscript> fixation, is described. The productive merger of a Ni-catalyzed cross-electrophile coupling manifold, with the use of AlCl <subscript>3</subscript> , triggered a cascade reaction with the formation of three consecutive C-C bonds in a single operation. This strategy traces an unprecedented synthetic route to ketones under Lewis acid assisted carbon dioxide valorization. Computational insights revealed a unique double function of AlCl <subscript>3</subscript> , and labeling ( <superscript>13</superscript> CO <subscript>2</subscript> ) experiments validate the genuine incorporation of CO <subscript>2</subscript> in both functional groups.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 25
- Issue :
- 38
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 37669466
- Full Text :
- https://doi.org/10.1021/acs.orglett.3c02394