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The potential of Acmella oleracea as a nutraceutical source for the symptomatic treatment of Burning Mouth Syndrome.

Authors :
Paolla Raimundo E Silva J
Raimundo E Silva JP
Silva Vasconcelos PG
Targino Campos L
de Medeiros Gomes J
Tolentino Leite Filho M
Menezes RPB
Scotti MT
Tavares JF
Cristina Barbosa Silva A
Costa EMMB
Source :
Natural product research [Nat Prod Res] 2024 Oct; Vol. 38 (20), pp. 3535-3541. Date of Electronic Publication: 2023 Sep 06.
Publication Year :
2024

Abstract

This study analysed the phytochemical profile of Acmella oleracea extract and the molecular interactions of its main compounds with TRPV1 and CB2, target receptors in the Burning Mouth Syndrome (BMS) pathogenesis. The phytochemical profile of A. oleracea' s floral buds extract treated with activated charcoal (TCEE) was analysed by High-Performance Liquid Chromatography (HPLC) coupled to Mass Spectrometry (LC-MS). The quantification of spilanthol was analysed by HPLC coupled to a Diode-Array Detector (HPLC-DAD). The phytochemical analysis revealed the presence of nine alkylamides and phenolic compounds. The TCEE showed a significant increase in spilanthol content compared to the crude extract (CEE), going from 28.33 mg/g to 117.96 mg/g. The molecular docking indicated a behaviour of the alkylamides as partial TRPV1 agonists and CB2 agonists and, for the first time, indicates the action of these compounds in the symptomatic management of BMS.

Details

Language :
English
ISSN :
1478-6427
Volume :
38
Issue :
20
Database :
MEDLINE
Journal :
Natural product research
Publication Type :
Academic Journal
Accession number :
37671677
Full Text :
https://doi.org/10.1080/14786419.2023.2253974