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Trace water in a BF 3 ·OEt 2 system: a facile access to sulfinyl alkenylsulfones from alkynes and sodium sulfinates.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2023 Oct 04; Vol. 21 (38), pp. 7776-7781. Date of Electronic Publication: 2023 Oct 04. - Publication Year :
- 2023
-
Abstract
- A highly efficient and operationally simple method for the synthesis of β-sulfinyl alkenylsulfones through a BF <subscript>3</subscript> ·OEt <subscript>2</subscript> -promoted reaction of alkynes and sodium sulfinates is developed, successfully avoiding the complicated anhydrous treatment before the reaction and greatly simplifying the reaction conditions. As a facile and selective route to the targets, it features good functional group compatibility, mild conditions, easily available starting materials, and excellent yields. Notably, the trace water in solvent plays a key role in promoting the reaction, which provides a more practical pathway for the utilization of the BF <subscript>3</subscript> ·OEt <subscript>2</subscript> catalytic system.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 21
- Issue :
- 38
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 37701943
- Full Text :
- https://doi.org/10.1039/d3ob01249b