Back to Search
Start Over
Wireless electrical-molecular quantum signalling for cancer cell apoptosis.
- Source :
-
Nature nanotechnology [Nat Nanotechnol] 2024 Jan; Vol. 19 (1), pp. 106-114. Date of Electronic Publication: 2023 Sep 14. - Publication Year :
- 2024
-
Abstract
- Quantum biological tunnelling for electron transfer is involved in controlling essential functions for life such as cellular respiration and homoeostasis. Understanding and controlling the quantum effects in biology has the potential to modulate biological functions. Here we merge wireless nano-electrochemical tools with cancer cells for control over electron transfer to trigger cancer cell death. Gold bipolar nanoelectrodes functionalized with redox-active cytochrome c and a redox mediator zinc porphyrin are developed as electric-field-stimulating bio-actuators, termed bio-nanoantennae. We show that a remote electrical input regulates electron transport between these redox molecules, which results in quantum biological tunnelling for electron transfer to trigger apoptosis in patient-derived cancer cells in a selective manner. Transcriptomics data show that the electric-field-induced bio-nanoantenna targets the cancer cells in a unique manner, representing electrically induced control of molecular signalling. The work shows the potential of quantum-based medical diagnostics and treatments.<br /> (© 2023. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1748-3395
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature nanotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 37709951
- Full Text :
- https://doi.org/10.1038/s41565-023-01496-y