Back to Search
Start Over
Real-time semantic segmentation and anomaly detection of functional images for cell therapy manufacturing.
- Source :
-
Cytotherapy [Cytotherapy] 2023 Dec; Vol. 25 (12), pp. 1361-1369. Date of Electronic Publication: 2023 Sep 18. - Publication Year :
- 2023
-
Abstract
- Background Aims: Cell therapy is a promising treatment method that uses living cells to address a variety of diseases and conditions, including cardiovascular diseases, neurologic disorders and certain cancers. As interest in cell therapy grows, there is a need to shift to a more efficient, scalable and automated manufacturing process that can produce high-quality products at a lower cost.<br />Methods: One way to achieve this is using non-invasive imaging and real-time image analysis techniques to monitor and control the manufacturing process. This work presents a machine learning-based image analysis pipeline that includes semantic segmentation and anomaly detection capabilities.<br />Results/conclusions: This method can be easily implemented even when given a limited dataset of annotated images, is able to segment cells and debris and can identify anomalies such as contamination or hardware failure.<br />Competing Interests: Declaration of Competing Interest The authors have no commercial, proprietary or financial interest in the products or companies described in this article.<br /> (Copyright © 2023 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Image Processing, Computer-Assisted methods
Semantics
Machine Learning
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2566
- Volume :
- 25
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cytotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 37725031
- Full Text :
- https://doi.org/10.1016/j.jcyt.2023.08.011