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A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data.
- Source :
-
Epigenetics [Epigenetics] 2023 Dec; Vol. 18 (1), pp. 2257437. Date of Electronic Publication: 2023 Sep 20. - Publication Year :
- 2023
-
Abstract
- Background: Recent studies have identified thousands of associations between DNA methylation CpGs and complex diseases/traits, emphasizing the critical role of epigenetics in understanding disease aetiology and identifying biomarkers. However, association analyses based on methylation array data are susceptible to batch/slide effects, which can lead to inflated false positive rates or reduced statistical power Results: We use multiple DNA methylation datasets based on the popular Illumina Infinium MethylationEPIC BeadChip array to describe consistent patterns and the joint distribution of slide effects across CpGs, confirming and extending previous results. The susceptible CpGs overlap with the Illumina Infinium HumanMethylation450 BeadChip array content. Conclusions: Our findings reveal systematic patterns in slide effects. The observations provide further insights into the characteristics of these effects and can improve existing adjustment approaches.
- Subjects :
- Epigenomics
Multifactorial Inheritance
DNA Methylation
Epigenesis, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1559-2308
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Epigenetics
- Publication Type :
- Academic Journal
- Accession number :
- 37731367
- Full Text :
- https://doi.org/10.1080/15592294.2023.2257437