SARS-CoV-2 Infection Precipitating VT Storm in Patients With Cardiac Sarcoidosis.

The authors describe 3 patients presenting with cardiac sarcoidosis (CS) flare and ventricular tachycardia (VT) storm following infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19. COVID-19-related cardiac manifestations can vary and include arrythmias, myocarditis, and exacerbation of underlying cardiovascular disease. The exact mechanism of myocardial involvement is not clear but may include abnormal host immune response and direct myocardial injury, thereby predisposing to enhanced arrhythmic risk. Arrhythmias account for 20% of COVID-19-related complications with ventricular arrythmias occurring in 5.9% of cases. Further studies are needed to better understand mechanisms underlying the intersection between COVID-19 infection and inflammatory cardiomyopathies.
Competing Interests: Funding Support and Author Disclosures Dr John was supported by the Pierce Family Fellowship. Dr Winterfield has received institutional research support from Abbott Medical and Biosense Webster; and has received consulting fees from Abbott Medical, Biosense Webster, Thermedical, and Biotronik. Dr Houston has received institutional research support from Medtronic Inc and CVRx; and has received consulting fees from Edwards Lifesciences and Medtronic. Dr Tedrow has received consulting fees from Biosense Webster and Thermedical Inch; has served on an advisory board for Biosense Webster; and has received honoraria for educational courses from Biosense Webster, Boston Scientific, Medtronic, and Abbott medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
(Copyright © 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)