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Metabolites isolated from the mangrove endophytic fungus Didymella sp. CYSK-4 and their cytotoxic activities.
- Source :
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Fitoterapia [Fitoterapia] 2023 Dec; Vol. 171, pp. 105692. Date of Electronic Publication: 2023 Sep 26. - Publication Year :
- 2023
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Abstract
- Two new 12- or 13- membered-ring macrocyclic alkaloids ascomylactam D and E (1 & 2), and a pair of new enantiomer (+)- and (-)- didymetone (3) were purified from the mangrove endophytic fungus Didymella sp. CYSK-4. Their structures and absolute configurations were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, ECD and <superscript>13</superscript> C NMR calculations. Compound 2 exhibited significant cytotoxicity against human A549 and KYSE 150 cancer cell lines with IC <subscript>50</subscript> values of 2.8 μM and 5.9 μM, respectively.<br />Competing Interests: Declaration of Competing Interest The authors declare that there is no conflict of interest.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 171
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 37757921
- Full Text :
- https://doi.org/10.1016/j.fitote.2023.105692