Modeling of Alzheimer's Disease to Study the Efficacy of Cell Therapy (Review).

Authors :: Voronova AD
Karsuntseva EK
Stepanova OV
Chadin AV
Shishkina VV
Andretsova SS
Fursa GA
Shport SV
Reshetov IV
Chekhonin VP
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Aug; Vol. 175 (4), pp. 524-529. Date of Electronic Publication: 2023 Sep 28.
Publication Year :: 2023
Abstract: We analyzed the main approaches to the modeling of Alzheimer's disease for studying the effectiveness of cell therapy. Recent advances in regenerative medicine in the field of neuroscience create prospects for the use of various cell preparations for the treatment of Alzheimer's disease. Experimental data on the use of neural stem/progenitor cells, mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells in various models of Alzheimer's disease are presented. Of particular importance is the standardization of protocols. The use of a standardized protocol in modeling of Alzheimer's disease will allow a comparative analysis of the effectiveness and safety of treatment to identify the optimal cell preparation. The data obtained on experimental animals can form the basis for further preclinical and clinical studies of cell therapy for Alzheimer's disease.<br /> (© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)