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Comparison between available early antiviral treatments in outpatients with SARS-CoV-2 infection: a real-life study.
- Source :
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BMC infectious diseases [BMC Infect Dis] 2023 Oct 02; Vol. 23 (1), pp. 646. Date of Electronic Publication: 2023 Oct 02. - Publication Year :
- 2023
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Abstract
- Purpose: To investigate the clinical impact of three available antivirals for early COVID-19 treatment in a large real-life cohort.<br />Methods: Between January and October 2022 all outpatients tested positive for SARS-CoV-2 referring to IRCCS S. Orsola hospital treated with an early antiviral therapy were enrolled. A comparison between patients treated with nirmatrelvir/ritonavir (NTV/r), molnupiravir (MPV) and remdesivir (RDV) was conducted in term of indications and outcome. To account for differences between treatment groups a propensity score analysis was performed. After estimating the weights, we fitted a survey-weighted Cox regression model with inverse-probability weighting with hospital admission/death versus clinical recovery as the primary outcome.<br />Results: Overall 1342 patients were enrolled, 775 (57.8%), 360 (26.8%) and 207 (15.4%) in MPV, NTV/r and RDV group, respectively. Median age was 73 (59-82) years, male sex was 53.4%. Primary indication was immunosuppression (438, 32.6%), the median time from symptom onset to drug administration was 3 [2-4] days. Overall, clinical recovery was reached in 96.9% of patients, with hospital admission rate of 2.6%. No significant differences were found in clinical recovery nor hospitalization. Cox regression showed a decreased probability of hospital admission/ death among prior vaccinated patients compared with unvaccinated (HR 0.31 [95%CI 0.14-0.70], pā=ā0.005]). No difference in hospitalization rates in early treatment compared to late treatment were found.<br />Conclusions: No differences among MPV, NTV/r and RDV in terms of clinical recovery or hospitalization were found. Patients not vaccinated had a significant increased risk of hospitalization.<br /> (© 2023. BioMed Central Ltd., part of Springer Nature.)
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 37784051
- Full Text :
- https://doi.org/10.1186/s12879-023-08538-9