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Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI.
- Source :
-
Research square [Res Sq] 2023 Sep 15. Date of Electronic Publication: 2023 Sep 15. - Publication Year :
- 2023
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Abstract
- Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat due to multi-drug resistance development among the CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections. Catheter-induced inflammation promotes fibrinogen (Fg) and fibrin accumulation in the bladder which are exploited as a biofilm formation platform by CAUTI pathogens. Using our established mouse model of CAUTI, we identified that host populations exhibiting either genetic or acquired fibrinolytic-deficiencies, inducing fibrin deposition in the catheterized bladder, are predisposed to severe CAUTI and septicemia by diverse uropathogens in mono- and poly-microbial infections. Furthermore, we found that E. faecalis , a prevalent CAUTI pathogen, uses the secreted protease, SprE, to induce fibrin accumulation and create a niche ideal for growth, biofilm formation, and persistence during CAUTI.<br />Competing Interests: Declaration of interests: The authors declare no competing financial interests.
Details
- Language :
- English
- Database :
- MEDLINE
- Journal :
- Research square
- Accession number :
- 37790429
- Full Text :
- https://doi.org/10.21203/rs.3.rs-3263501/v1