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Serum irisin levels are negatively associated with blood pressure in dialysis patients.
Serum irisin levels are negatively associated with blood pressure in dialysis patients.
- Source :
-
Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2023 Dec; Vol. 46 (12), pp. 2738-2745. Date of Electronic Publication: 2023 Oct 04. - Publication Year :
- 2023
-
Abstract
- Elevated blood pressure is highly prevalent among dialysis patients and is associated with high mortality. Irisin is a newly found myokine that has been indicated to be related to blood pressure regulation in animal experiments. Data regarding the effect of serum irisin levels on blood pressure in dialysis patients are limited. To identify the association between serum irisin levels and blood pressure and examine determinant factors of systolic blood pressure in dialysis patients, we recruited 300 dialysis patients at Xuanwu Hospital Capital Medical University. Serum irisin levels were assessed by enzyme-linked immunosorbent assay kits. Blood pressure was self-measured on 7 consecutive days by an automated sphygmomanometer. The Pearson correlation test showed that the natural logarithm of irisin was negatively correlated with systolic blood pressure (r = -0.462, P < 0.001) and pulse pressure (r = -0.487, P < 0.001), but not correlated with diastolic blood pressure (r = -0.022, P = 0.709). Multivariate analysis revealed that the natural logarithm of irisin (β = -0.336, P < 0.001), lean tissue mass (β = 0.164, P = 0.005), diabetes mellitus (β = 0.165, P = 0.003) and serum calcium (β = -0.135, P = 0.019) were significant determinant factors for systolic blood pressure. This study is the first to demonstrate that serum irisin levels are significantly negatively associated with blood pressure in dialysis patients. Further studies are needed to provide possible mechanisms. We demonstrated that serum irisin levels were negatively associated with blood pressure in dialysis patients, which may provide a new target for antihypertensive treatment.<br /> (© 2023. The Author(s), under exclusive licence to The Japanese Society of Hypertension.)
- Subjects :
- Humans
Blood Pressure
Fibronectins
Renal Dialysis
Diabetes Mellitus
Hypertension
Subjects
Details
- Language :
- English
- ISSN :
- 1348-4214
- Volume :
- 46
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Hypertension research : official journal of the Japanese Society of Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 37794242
- Full Text :
- https://doi.org/10.1038/s41440-023-01449-x