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Longitudinal associations of cardiovascular health and vascular events with incident dementia.
- Source :
-
Stroke and vascular neurology [Stroke Vasc Neurol] 2024 Aug 27; Vol. 9 (4), pp. 418-428. Date of Electronic Publication: 2024 Aug 27. - Publication Year :
- 2024
-
Abstract
- Introduction: Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented. A comprehensive study to illuminate the distinctive associations across different dementia types is still lacking. This study is sought to: (1) determine the clinical validity of Framingham General Cardiovascular Risk Score (FGCRS) for dementia assessment and (2) examine the associations between cardiovascular diseases and the risk of dementia.<br />Methods: A total of 432 079 dementia-free individuals at baseline from UK Biobank were included. Multivariable Cox proportional hazard models were used to investigate the prospective associations for FGCRS and a series of cardiovascular diseases with all-cause dementia (ACD) and its major components, Alzheimer's disease (AD) and vascular dementia (VaD).<br />Results: During a median follow-up of 110.1 months, 4711 individuals were diagnosed with dementia. FGCRS was associated with increased risks across the dementia spectrum. In stratification analysis, high-risk groups have demonstrated the greatest dementia burdens, particularly to VaD. Over 74 traits, 9 adverse associations, such as chronic ischaemic heart disease (ACD: HR=1.354; AD: HR=1.269; VaD: HR=1.768), atrioventricular block (ACD: HR=1.562; AD: HR=1.556; VaD: HR=2.069), heart failure (ACD: HR=1.639; AD: HR=1.543; VaD: HR=2.141) and hypotension (ACD: HR=2.912; AD: HR=2.361; VaD: HR=3.315) were observed. Several distinctions were also found, with atrial fibrillation, cerebral infarction, and haemorrhage only associated with greater risks of ACD and VaD.<br />Discussion: By identifying distinctive associations between cardiovascular diseases and dementia, this study has established a comprehensive 'mapping' that may untangle the long-standing discrepancy. FGCRS has demonstrated its predictivity beyond cardiovascular diseases burdens, suggesting potential opportunities for implantation.<br />Competing Interests: Competing interests: None declared.<br /> (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Humans
Male
Female
Risk Assessment
Aged
Middle Aged
Time Factors
United Kingdom epidemiology
Incidence
Longitudinal Studies
Prognosis
Dementia, Vascular epidemiology
Dementia, Vascular diagnosis
Prospective Studies
Heart Disease Risk Factors
Risk Factors
Predictive Value of Tests
Cardiovascular Diseases epidemiology
Cardiovascular Diseases diagnosis
Dementia epidemiology
Dementia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2059-8696
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Stroke and vascular neurology
- Publication Type :
- Academic Journal
- Accession number :
- 37827852
- Full Text :
- https://doi.org/10.1136/svn-2023-002665