First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia.

Authors :: Chabala C
Jacobs TG
Moraleda C
Ndaferankhande JM
Mumbiro V
Passanduca A
Namuziya N
Nalwanga D
Musiime V
Ballesteros A
Domínguez-Rodríguez S
Chitsamatanga M
Cassia U
Nduna B
Bramugy J
Sacarlal J
Madrid L
Nathoo KJ
Colbers A
Burger DM
Mulenga V
Buck WC
Mujuru HA
Te Brake LHM
Rojo P
Tagarro A
Aarnoutse RE
Source :: Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2023 Nov 30; Vol. 12 (11), pp. 581-585.
Publication Year :: 2023
Abstract: Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.<br /> (© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society.)

Subjects :: Adult
Infant
Humans
Antitubercular Agents
Reference Values
HIV Infections complications
HIV Infections drug therapy
Pneumonia drug therapy

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