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Allogeneic hematopoetic stem cell transplant for patients with refractory T-Cell lymphomas.
- Source :
-
European journal of haematology [Eur J Haematol] 2024 Feb; Vol. 112 (2), pp. 276-285. Date of Electronic Publication: 2023 Oct 16. - Publication Year :
- 2024
-
Abstract
- Objective: Allogeneic stem cell transplantation (allo-SCT) may have a curative potential due to the graft versus lymphoma effect. In this study, we aimed to compare transplant outcomes between refractory-T-NHL (ref-NHL) and Chemosensitive-T-NHL (CS-T-NHL).<br />Materials and Methods: We retrospectively reviewed the records of 26 ref-NHL and 29 CS-T-NHL consecutive patients who underwent allo-SCT at our center and compared the transplant outcomes between the groups.<br />Results: All patients were heavily pretreated with 27% of patients relapsing post-auto-SCT and two patients in the ref-T-NHL post-allo-SCT. Patients were transplanted mainly from unrelated donors. There were no differences in leucocytes and platelet engraftment between the two groups. At 3 years, the relapse incidence was 34% in Ref-TNHL and 19% in CS-TNHL (p = .33), with non-relapse mortality rates of 28% and 22%, respectively (p = .52). Female patients and those with a previous auto-SCT had lower relapse incidence (p = .045, p = .003). The 3-year overall survival was 39% in Ref-TNHL and 56% in CS-TNHL (p = .15). Trends for improved progression-free survival (PFS) and graft-versus-host disease relapse-free survival (GRFS) were observed in the CS-TNHL group (PFS: 60% vs. 30%, p = .075; GRFS: 38% vs. 21%, p = .1).<br />Conclusion: Acknowledging the retrospective nature of our study, our results indicate that allo-SCT has a curative potential in patients with T-NHL even in refractory status.<br /> (© 2023 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.)
- Subjects :
- Humans
Female
Retrospective Studies
Transplantation, Homologous methods
Disease-Free Survival
Neoplasm Recurrence, Local
Stem Cell Transplantation adverse effects
Chronic Disease
Recurrence
Lymphoma, Non-Hodgkin
Hematopoietic Stem Cell Transplantation adverse effects
Hematopoietic Stem Cell Transplantation methods
Lymphoma, T-Cell complications
Graft vs Host Disease etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0609
- Volume :
- 112
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 37845834
- Full Text :
- https://doi.org/10.1111/ejh.14113