Association Between Nurse Copatient Illness Severity and Mortality in the ICU.

Objectives: In the context of traditional nurse-to-patient ratios, ICU patients are typically paired with one or more copatients, creating interdependencies that may affect clinical outcomes. We aimed to examine the effect of copatient illness severity on ICU mortality.
Design: We conducted a retrospective cohort study using electronic health records from a multihospital health system from 2018 to 2020. We identified nurse-to-patient assignments for each 12-hour shift using a validated algorithm. We defined copatient illness severity as whether the index patient's copatient received mechanical ventilation or vasoactive support during the shift. We used proportional hazards regression with time-varying covariates to assess the relationship between copatient illness severity and 28-day ICU mortality.
Setting: Twenty-four ICUs in eight hospitals.
Patients: Patients hospitalized in the ICU between January 1, 2018, and August 31, 2020.
Interventions: None.
Measurements and Main Results: The main analysis included 20,650 patients and 84,544 patient-shifts. Regression analyses showed a patient's risk of death increased when their copatient received both mechanical ventilation and vasoactive support (hazard ratio [HR]: 1.30; 95% CI, 1.05-1.61; p = 0.02) or vasoactive support alone (HR: 1.82; 95% CI, 1.39-2.38; p < 0.001), compared with situations in which the copatient received neither treatment. However, if the copatient was solely on mechanical ventilation, there was no significant increase in the risk of death (HR: 1.03; 95% CI, 0.86-1.23; p = 0.78). Sensitivity analyses conducted on cohorts with varying numbers of copatients consistently showed an increased risk of death when a copatient received vasoactive support.
Conclusions: Our findings suggest that considering copatient illness severity, alongside the existing practice of considering individual patient conditions, during the nurse-to-patient assignment process may be an opportunity to improve ICU outcomes.
Competing Interests: Funding for this study was provided by the National Institutes of Health (NIH) (T32HL007820, Kahn, PI; R35HL144804, Kahn, PI). Drs. Kahn’s, Riman’s, and Davis’ institutions received funding from the NIH; they received support for article research from the NIH. The remaining author disclosed that they do not have any potential conflicts of interest.
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