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Clinical impact of sarcopenia for overweight or obese patients with colorectal cancer.

Authors :
Chen WZ
Lin F
Yu DY
Ren Q
Zhang FM
Shen ZL
Chen WH
Dong QT
Yu Z
Source :
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2024 Jan 07; Vol. 54 (1), pp. 23-30.
Publication Year :
2024

Abstract

Background: Sarcopenia, overweight and obesity are all dynamic changes in body composition, which may have a negative effect on the prognosis for patients with colorectal cancer. The aim of this study was to investigate the predictive role of sarcopenia on overweight or obese patients with colorectal cancer.<br />Methods: We conducted an observative study on the population of overweight or obese patients with colorectal cancer who underwent curative surgeries in two centers between 2015 and 2021. They were grouped by the presence of sarcopenia. Propensity score match analysis was used to balance the baseline of clinicopathologic characteristics of the two groups. Then, the postoperative outcomes between the two groups were compared. Independent risk factors were evaluated for complications using univariate and multivariate analysis.<br />Results: Of 827 patients enrolled, 126 patients were matched for analysis. Patients with sarcopenia had a higher incidence of total complication and medical complications, a higher rate of laparoscopic surgery performed and higher hospitalization costs. Old age (≥65 years, P = 0.012), ASA grade (III, P = 0.008) and sarcopenia (P = 0.036) were independent risk factors for total complications. ASA grade (III, P = 0.002) and sarcopenia (P = 0.017) were independent risk factors for medical complications.<br />Conclusions: Sarcopenia was prevalent among overweight or obese patients with colorectal cancer and was associated with negative postoperative outcomes. Early recognition of changes in body composition could help surgeons be well prepared for surgical treatment for overweight or obese patients.<br /> (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)

Details

Language :
English
ISSN :
1465-3621
Volume :
54
Issue :
1
Database :
MEDLINE
Journal :
Japanese journal of clinical oncology
Publication Type :
Academic Journal
Accession number :
37850297
Full Text :
https://doi.org/10.1093/jjco/hyad139