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Atractylenolide I improves behaviors in mice with depression-like phenotype by modulating neurotransmitter balance via 5-HT2A.
- Source :
-
Phytotherapy research : PTR [Phytother Res] 2024 Jan; Vol. 38 (1), pp. 231-240. Date of Electronic Publication: 2023 Oct 19. - Publication Year :
- 2024
-
Abstract
- To explore the antidepressant effects and targets of atractylenolide I (ATR) through a network pharmacological approach. Relevant targets of ATR and depression analyzed by network pharmacology were scored (identifying 5-HT2A targets). Through elevated plus maze, open field, tail suspension, and forced swimming tests, the behavioral changes of mice with depression (chronic unpredictable mild stress [CUMS]) were examined, and the levels of neurotransmitters including serotonin, dopamine, and norepinephrine (5-HT, DA, and NE) were determined. The binding of ATR to 5-HT2A was verified by small molecular-protein docking. ATR improved the behaviors of CUMS mice, elevated their levels of neurotransmitters 5-HT, DA, and NE, and exerted a protective effect on their nerve cell injury. After 5-HT2A knockout, ATR failed to further improve the CUMS behaviors. According to the results of small molecular-protein docking and network pharmacological analysis, ATR acted as an inhibitor by binding to 5-HT2A. ATR can improve the behaviors and modulate the neurotransmitters of CUMS mice by targeting 5-HT2A.<br /> (© 2023 John Wiley & Sons Ltd.)
- Subjects :
- Mice
Animals
Antidepressive Agents pharmacology
Antidepressive Agents therapeutic use
Neurotransmitter Agents metabolism
Stress, Psychological drug therapy
Stress, Psychological metabolism
Disease Models, Animal
Hippocampus
Behavior, Animal
Depression drug therapy
Depression metabolism
Serotonin metabolism
Lactones
Sesquiterpenes
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1573
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Phytotherapy research : PTR
- Publication Type :
- Academic Journal
- Accession number :
- 37857401
- Full Text :
- https://doi.org/10.1002/ptr.8045