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A case of meningoencephalitis caused by multisystem inflammatory syndrome in adult SARS-CoV-2 infection.
- Source :
-
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2024 Mar; Vol. 30 (3), pp. 263-265. Date of Electronic Publication: 2023 Oct 19. - Publication Year :
- 2024
-
Abstract
- A 37-year-old woman was hospitalized with fever and consciousness disturbance. She showed systemic inflammation with stress cardiomyopathy. Brain computed tomography showed diffuse brain edema. Cerebrospinal fluid (CSF) findings revealed markedly elevated cerebrospinal fluid pressure with pleocytosis, elevated protein, and elevated interleukin 6. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nicking enzyme amplification reaction test using a nasopharyngeal swab was positive, and the patient was diagnosed with SARS-CoV-2 infection. From the negative result of the CSF SARS-CoV-2 polymerase chain reaction test and no findings of bacterial or viral infection, we diagnosed meningoencephalitis by multisystem inflammation syndrome in adults (MIS-A). Intravenous methylprednisolone pulse therapy improved her symptoms and brain edema. There have been no cases of MIS-A with meningoencephalitis, and no initial treatment strategy has been established, especially in emergency cases of suspected MIS-A. The present case suggested Early intravenous methylprednisolone pulse with anti-coronaviral therapies after the exclusion of bacterial infection would be useful in suspected MIS-A with emergent meningoencephalitis cases.<br />Competing Interests: Declaration of competing interest The authors declare no conflict of interest.<br /> (Copyright © 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Adult
Female
SARS-CoV-2
Systemic Inflammatory Response Syndrome complications
Systemic Inflammatory Response Syndrome diagnosis
Systemic Inflammatory Response Syndrome drug therapy
Inflammation
Methylprednisolone therapeutic use
COVID-19 complications
COVID-19 diagnosis
Brain Edema
Meningoencephalitis diagnosis
Meningoencephalitis drug therapy
Connective Tissue Diseases
Subjects
Details
- Language :
- English
- ISSN :
- 1437-7780
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
- Publication Type :
- Report
- Accession number :
- 37863259
- Full Text :
- https://doi.org/10.1016/j.jiac.2023.10.013