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Potential of thermoresponsive hydrogel as an alternative therapy for rat knee osteoarthritis.
- Source :
-
Journal of biomaterials applications [J Biomater Appl] 2023 Nov; Vol. 38 (5), pp. 707-718. Date of Electronic Publication: 2023 Oct 22. - Publication Year :
- 2023
-
Abstract
- Osteoarthritis is a degenerative condition that is highly prevalent and primarily affects the joints. The knee is the most commonly affected site, impacting the lives of over 300 million individuals worldwide. This study presents a potential solution to address the unmet need for a minimally invasive technique in the treatment of osteoarthritis: a biocompatible, injectable, and thermoresponsive hydrogel. In comparison to commercially available products such as lyophilized platelets, dextrose, and triamcinolone, the thermoresponsive hydrogel exhibits significantly superior performance in dynamic behaviors, including print area, stability, and step cycle, when tested on rats with knee osteoarthritis. However, it demonstrates similar treatment efficacy to these products in static behaviors, as observed through histopathological and immunohistochemical analysis. Therefore, the thermoresponsive hydrogel holds promise as an effective alternative therapy for osteoarthritis. Moreover, by blending the hydrogel with drugs, controlled and sustained release can be achieved, thereby facilitating the long-term management of osteoarthritis symptoms.<br />Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Rats
Animals
Knee Joint
Hydrogels
Osteoarthritis, Knee drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1530-8022
- Volume :
- 38
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of biomaterials applications
- Publication Type :
- Academic Journal
- Accession number :
- 37867223
- Full Text :
- https://doi.org/10.1177/08853282231208506