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A single photoreceptor splits perception and entrainment by cotransmission.
- Source :
-
Nature [Nature] 2023 Nov; Vol. 623 (7987), pp. 562-570. Date of Electronic Publication: 2023 Oct 25. - Publication Year :
- 2023
-
Abstract
- Vision enables both image-forming perception, driven by a contrast-based pathway, and unconscious non-image-forming circadian photoentrainment, driven by an irradiance-based pathway <superscript>1,2</superscript> . Although two distinct photoreceptor populations are specialized for each visual task <superscript>3-6</superscript> , image-forming photoreceptors can additionally contribute to photoentrainment of the circadian clock in different species <superscript>7-15</superscript> . However, it is unknown how the image-forming photoreceptor pathway can functionally implement the segregation of irradiance signals required for circadian photoentrainment from contrast signals required for image perception. Here we report that the Drosophila R8 photoreceptor separates image-forming and irradiance signals by co-transmitting two neurotransmitters, histamine and acetylcholine. This segregation is further established postsynaptically by histamine-receptor-expressing unicolumnar retinotopic neurons and acetylcholine-receptor-expressing multicolumnar integration neurons. The acetylcholine transmission from R8 photoreceptors is sustained by an autocrine negative feedback of the cotransmitted histamine during the light phase of light-dark cycles. At the behavioural level, elimination of histamine and acetylcholine transmission impairs R8-driven motion detection and circadian photoentrainment, respectively. Thus, a single type of photoreceptor can achieve the dichotomy of visual perception and circadian photoentrainment as early as the first visual synapses, revealing a simple yet robust mechanism to segregate and translate distinct sensory features into different animal behaviours.<br /> (© 2023. The Author(s).)
- Subjects :
- Animals
Acetylcholine metabolism
Biological Clocks physiology
Biological Clocks radiation effects
Feedback, Physiological
Histamine metabolism
Neurotransmitter Agents metabolism
Receptors, Cholinergic metabolism
Receptors, Histamine metabolism
Circadian Rhythm physiology
Circadian Rhythm radiation effects
Drosophila melanogaster cytology
Drosophila melanogaster physiology
Drosophila melanogaster radiation effects
Photoreceptor Cells, Invertebrate metabolism
Photoreceptor Cells, Invertebrate radiation effects
Visual Perception physiology
Visual Perception radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 623
- Issue :
- 7987
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 37880372
- Full Text :
- https://doi.org/10.1038/s41586-023-06681-6