The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia.

Authors :: Whiteside GT
Kyle DJ
Kapil RP
Cipriano A
He E
Zhou M
Shet MS
Hummel M
Knappenberger T
Fukumura K
Matsuo Y
Uehira M
Hiroyama S
Takai N
Willsie SK
Harris SC
Source :: The Journal of clinical investigation [J Clin Invest] 2024 Jan 02; Vol. 134 (1). Date of Electronic Publication: 2024 Jan 02.
Publication Year :: 2024
Abstract: The potent and partial agonist sunobinop activates the nociceptin/orphanin-FQ peptide receptor and promotes non-REM sleep in rodents and patients with insomnia.

Subjects :: Animals
Humans
Receptors, Opioid agonists
Receptors, Opioid physiology
Opioid Peptides
Nociceptin Receptor
Rodentia
Sleep
Nociceptin
Sleep Initiation and Maintenance Disorders drug therapy

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