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Transcending the challenge of evolving resistance mechanisms in Pseudomonas aeruginosa through β-lactam-enhancer-mechanism-based cefepime/zidebactam.
- Source :
-
MBio [mBio] 2023 Dec 19; Vol. 14 (6), pp. e0111823. Date of Electronic Publication: 2023 Oct 27. - Publication Year :
- 2023
-
Abstract
- Compared to other genera of Gram-negative pathogens, Pseudomonas is adept in acquiring complex non-enzymatic and enzymatic resistance mechanisms thus remaining a challenge to even novel antibiotics including recently developed β-lactam and β-lactamase inhibitor combinations. This study shows that the novel β-lactam enhancer approach enables cefepime/zidebactam to overcome both non-enzymatic and enzymatic resistance mechanisms associated with a challenging panel of P. aeruginosa . This study highlights that the β-lactam enhancer mechanism is a promising alternative to the conventional β-lactam/β-lactamase inhibitor approach in combating ever-evolving MDR P. aeruginosa .<br />Competing Interests: Some of the coauthors are employees of Wockhardt. R.A.B. receives grant funding from Wockhardt.
- Subjects :
- Drug Resistance, Multiple, Bacterial genetics
beta-Lactamase Inhibitors pharmacology
Cefepime pharmacology
Pseudomonas Infections microbiology
Pseudomonas Infections drug therapy
beta-Lactams pharmacology
Humans
beta-Lactamases genetics
beta-Lactamases metabolism
Drug Combinations
Piperidines
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa genetics
Anti-Bacterial Agents pharmacology
Azabicyclo Compounds pharmacology
Cyclooctanes pharmacology
Microbial Sensitivity Tests
Cephalosporins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2150-7511
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- MBio
- Publication Type :
- Academic Journal
- Accession number :
- 37889005
- Full Text :
- https://doi.org/10.1128/mbio.01118-23