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Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways.
- Source :
-
Nature communications [Nat Commun] 2023 Oct 27; Vol. 14 (1), pp. 6853. Date of Electronic Publication: 2023 Oct 27. - Publication Year :
- 2023
-
Abstract
- Although the gut microbiota has been reported to influence osteoporosis risk, the individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese cohort of peri-/post-menopausal women with metagenomics/targeted metabolomics/whole-genome sequencing to identify novel microbiome-related biomarkers for bone health. Bacteroides vulgatus was found to be negatively associated with bone mineral density (BMD), which was validated in US white people. Serum valeric acid (VA), a microbiota derived metabolite, was positively associated with BMD and causally downregulated by B. vulgatus. Ovariectomized mice fed B. vulgatus demonstrated increased bone resorption and poorer bone micro-structure, while those fed VA demonstrated reduced bone resorption and better bone micro-structure. VA suppressed RELA protein production (pro-inflammatory), and enhanced IL10 mRNA expression (anti-inflammatory), leading to suppressed maturation of osteoclast-like cells and enhanced maturation of osteoblasts in vitro. The findings suggest that B. vulgatus and VA may represent promising targets for osteoporosis prevention/treatment.<br /> (© 2023. The Author(s).)
- Subjects :
- Humans
Female
Mice
Animals
Gastrointestinal Microbiome
Bone Resorption
Osteoporosis
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 37891329
- Full Text :
- https://doi.org/10.1038/s41467-023-42005-y