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Association of the lung immune prognostic index with the survival of patients with idiopathic interstitial pneumonias.
- Source :
-
Respirology (Carlton, Vic.) [Respirology] 2024 Feb; Vol. 29 (2), pp. 136-145. Date of Electronic Publication: 2023 Nov 03. - Publication Year :
- 2024
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Abstract
- Background and Objective: The lung immune prognostic index (LIPI), a simple index calculated from the blood lactate dehydrogenase level and derived neutrophil-to-lymphocyte ratio, is thought to be associated with host immune status. However, the utility of LIPI in patients with idiopathic interstitial pneumonias (IIPs) is unknown.<br />Methods: In this multicentre, retrospective, observational study, an association between LIPI and the survival of patients with IIPs was evaluated.<br />Results: Exploratory and validation cohorts consisting of 460 and 414 patients with IIPs, respectively, were included (159 and 159 patients had idiopathic pulmonary fibrosis [IPF], and 301 and 255 had non-IPF, respectively). In the exploratory cohort, patients with IPF and a low LIPI had significantly better survival than those with a high LIPI (median of 5.6 years vs. 3.9 years, p = 0.016). The predictive ability of LIPI for the survival of patients with IPF was validated in the validation cohort (median of 8.5 years vs. 4.4 years, p = 0.003). In a multivariate Cox proportional hazard analysis, LIPI was selected as an independent predictive factor for the survival of IPF patients. There was no significant association between LIPI and survival of non-IPF patients in the exploratory and validation cohorts.<br />Conclusion: The LIPI was a predictive factor for the survival of patients with IPF and could aid the management of IPF.<br /> (© 2023 Asian Pacific Society of Respirology.)
Details
- Language :
- English
- ISSN :
- 1440-1843
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Respirology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 37921012
- Full Text :
- https://doi.org/10.1111/resp.14621