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Long-term organ damage accrual and late mortality in systemic sclerosis.
- Source :
-
Clinical and experimental rheumatology [Clin Exp Rheumatol] 2024 Aug; Vol. 42 (8), pp. 1541-1548. Date of Electronic Publication: 2023 Oct 27. - Publication Year :
- 2024
-
Abstract
- Objectives: Progressive organ damage accrual in patients with systemic sclerosis (SSc) can be measured using the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI). We aimed to evaluate the long-term evolution of organ damage accrual in SSc patients with at least 10 years of follow-up, identifying clinical and laboratory features associated with moderate and severe damage, and the association of SCTC-DI with "late mortality" (death >10 years after diagnosis).<br />Methods: In this single-centre retrospective study, patients with SSc were included when fulfilling the following characteristics: 1) a baseline visit corresponding to the time of diagnosis; 2) a minimum of 10 years of follow-up after diagnosis; 3) available follow-up visits at predefined timepoints.<br />Results: In 253 patients included in the study, SCTC-DI progressively increased from the baseline to 10 years after diagnosis, with 34% of patients showing moderate or severe damage at this time point. During the follow-up, the SCTC-DI score was higher, and had a higher annual rise, in dcSSc patients than in lcSSc and in ACA-negative patients than in ACA+. Multivariable analyses identified dcSSc, lack of ACA, and the SCTC-DI scores at previous timepoints as independent variables associated with moderate or severe damage. In patients with "late mortality", as compared to surviving patients, the SCTC-DI score was demonstrated to be significantly higher at the baseline and at every timepoint, with a higher annual rise.<br />Conclusions: Factors associated with damage accrual in SSc patients with long-term follow-up were identified. Higher SCTC-DI and higher SCTC-DI annual rise were associated with late mortality in SSc.
- Subjects :
- Humans
Female
Male
Retrospective Studies
Middle Aged
Adult
Time Factors
Risk Factors
Aged
Scleroderma, Systemic mortality
Scleroderma, Systemic diagnosis
Multivariate Analysis
Prognosis
Predictive Value of Tests
Scleroderma, Diffuse mortality
Scleroderma, Diffuse complications
Scleroderma, Diffuse diagnosis
Disease Progression
Severity of Illness Index
Subjects
Details
- Language :
- English
- ISSN :
- 0392-856X
- Volume :
- 42
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical and experimental rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 37933549
- Full Text :
- https://doi.org/10.55563/clinexprheumatol/2xiitt